Inhibition of Ras function in vitro and in vivo using inhibitors of farnesyl-protein transferase

Methods Enzymol. 1995:255:378-86. doi: 10.1016/s0076-6879(95)55040-2.

Authors

N E Kohl¹, F R Wilson, T J Thomas, R L Bock, S D Mosser, A Oliff, J B Gibbs

Affiliation

¹ Department of Cancer Research, Merck Research Laboratories, West Point, Pennsylvania 19486, USA.

PMID: 8524123
DOI: 10.1016/s0076-6879(95)55040-2

No abstract available

MeSH terms

3T3 Cells
Alkyl and Aryl Transferases*
Animals
Cell Line
Dipeptides / pharmacology
Enzyme Inhibitors / pharmacology
Humans
In Vitro Techniques
Mice
Protein Prenylation / drug effects
Rats
Transferases / antagonists & inhibitors*
ras Proteins / antagonists & inhibitors*

Substances

Dipeptides
Enzyme Inhibitors
L 731734
Transferases
Alkyl and Aryl Transferases
p21(ras) farnesyl-protein transferase
ras Proteins