Phagocytosis reduces HIV-1 production in human monocytes/macrophages infected in vitro

G Piedimonte; M Montroni; G Silvestri; L Silvotti; A Donatini; L Rossi; A F Borghetti; M Magnani

doi:10.1007/BF01309674

Phagocytosis reduces HIV-1 production in human monocytes/macrophages infected in vitro

Arch Virol. 1993;130(3-4):463-9. doi: 10.1007/BF01309674.

Authors

G Piedimonte¹, M Montroni, G Silvestri, L Silvotti, A Donatini, L Rossi, A F Borghetti, M Magnani

Affiliation

¹ Institute of General Pathology, University of Parma, Italy.

PMID: 8517797
DOI: 10.1007/BF01309674

Abstract

The addition of ingestable particles (opsonized erythrocytes or latex beads) or a phorbol ester activates monocytes--derived human macrophages (MDHM) cultured in vitro, and markedly reduces virion release from HIV-infected MDHM as well as their ability to transmit the infection to cocultured lymphoid CD4-positive CEM cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

HIV-1 / immunology
HIV-1 / physiology*
Humans
In Vitro Techniques
Macrophage Activation / physiology
Macrophages / immunology
Macrophages / microbiology*
Monocytes / immunology
Monocytes / microbiology*
Phagocytosis / physiology*
Virus Replication / immunology*