Leptolstatin from Streptomyces sp. SAM1595, a new gap phase-specific inhibitor of the mammalian cell cycle. II. Physico-chemical properties and structure

K Abe; M Yoshida; H Naoki; S Horinouchi; T Beppu

doi:10.7164/antibiotics.46.735

Leptolstatin from Streptomyces sp. SAM1595, a new gap phase-specific inhibitor of the mammalian cell cycle. II. Physico-chemical properties and structure

J Antibiot (Tokyo). 1993 May;46(5):735-40. doi: 10.7164/antibiotics.46.735.

Authors

K Abe¹, M Yoshida, H Naoki, S Horinouchi, T Beppu

Affiliation

¹ Department of Agricultural Chemistry, Faculty of Agriculture, University of Tokyo, Japan.

PMID: 8514627
DOI: 10.7164/antibiotics.46.735

Abstract

Leptolstatin, a product from Streptomyces sp. SAM1595, is a gap phase-specific inhibitor of the mammalian cell cycle. Physico-chemical properties and spectrometric analyses showed that the structure of leptolstatin is (2Z,6E,8Z,12E,14E,22E)-19,24-dihydro xy-8,10,14,16,18,20,22-heptamethyl-17-oxo-2 , 6,8,12,14,22-tetracosahexaen-5-olide.

MeSH terms

Animals
Antibiotics, Antineoplastic / chemistry*
Antibiotics, Antineoplastic / pharmacology
Cell Cycle / drug effects
Polyenes / chemistry*
Polyenes / pharmacology
Rats
Streptomyces / chemistry*
Structure-Activity Relationship

Substances

Antibiotics, Antineoplastic
Polyenes
leptolstatin