Abstract
We describe a method for use of fluorescent-labeled whole chromosome-specific paint probes on GTL-banded metaphases to utilize the combined potential of these techniques for defining chromosome abnormalities. The efficacy of this method was tested on 6 cases involving different chromosome abnormalities and various tissues, including blood, amniotic fluid, skin fibroblasts, and bone marrow.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Abnormalities, Multiple / genetics
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Abortion, Spontaneous / genetics
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Adult
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Amniocentesis
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Chromosome Banding / methods*
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Female
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Fluorescent Dyes
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Fragile X Syndrome / genetics
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Humans
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Hydrocephalus / genetics
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In Situ Hybridization, Fluorescence
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Infant
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Infant, Newborn
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Karyotyping
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Leukemia, Promyelocytic, Acute / genetics
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Male
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Metaphase
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Middle Aged
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Mosaicism
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Pregnancy
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Translocation, Genetic