Abstract
A method has been developed to track controlled drug release and transport in the brain. This method entails the use of a polymeric implant to release, over time, a paramagnetically labelled compound into the brain. Magnetic resonance imaging is used to determine the evolving concentration distribution. This method is well suited to other types of intracranial drug delivery systems as well as to track transport in other organs of the body.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Agar
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Animals
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Brain / metabolism*
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Contrast Media
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Delayed-Action Preparations
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Diffusion
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Drug Implants
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Gadolinium / administration & dosage
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Gadolinium / chemistry
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Gadolinium / pharmacokinetics*
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Gadolinium DTPA
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In Vitro Techniques
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Magnetic Resonance Imaging*
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Models, Chemical
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Organometallic Compounds / administration & dosage
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Organometallic Compounds / chemistry
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Organometallic Compounds / pharmacokinetics*
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Pentetic Acid / administration & dosage
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Pentetic Acid / chemistry
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Pentetic Acid / pharmacokinetics*
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Polymers
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Rabbits
Substances
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Contrast Media
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Delayed-Action Preparations
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Drug Implants
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Organometallic Compounds
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Polymers
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Pentetic Acid
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Agar
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Gadolinium
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Gadolinium DTPA
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gadolinium chloride