HLA-DR3, DQ2 homozygosity in two patients with insulin-dependent diabetes mellitus superimposed with ulcerative colitis and primary sclerosing cholangitis

S A Ivarsson; S Eriksson; I Kockum; A Lernmark; S Lindgren; K O Nilsson; G Sundkvist; R Wassmuth

doi:10.1111/j.1365-2796.1993.tb00988.x

HLA-DR3, DQ2 homozygosity in two patients with insulin-dependent diabetes mellitus superimposed with ulcerative colitis and primary sclerosing cholangitis

J Intern Med. 1993 Mar;233(3):281-6. doi: 10.1111/j.1365-2796.1993.tb00988.x.

Authors

S A Ivarsson¹, S Eriksson, I Kockum, A Lernmark, S Lindgren, K O Nilsson, G Sundkvist, R Wassmuth

Affiliation

¹ Department of Paediatrics, University of Lund, Malmö General Hospital, Sweden.

PMID: 8450297
DOI: 10.1111/j.1365-2796.1993.tb00988.x

Abstract

Two unrelated young males with the unusual simultaneous presence of insulin-dependent diabetes mellitus, ulcerative colitis and primary sclerosing cholangitis are reported. Both patients manifested homozygosity for the DR3-DQw2 (DQB*0201) HLA genotypes. We believe that homozygosity for this genotype may predispose for this type of multi-organ autoimmune disease.

Publication types

Case Reports
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Adolescent
Child
Cholangitis, Sclerosing / complications
Cholangitis, Sclerosing / genetics*
Colitis, Ulcerative / complications
Colitis, Ulcerative / genetics*
Diabetes Mellitus, Type 1 / complications
Diabetes Mellitus, Type 1 / genetics*
HLA-DQ Antigens / genetics*
HLA-DR3 Antigen / genetics*
Homozygote
Humans
Male

Substances

HLA-DQ Antigens
HLA-DQ2 antigen
HLA-DR3 Antigen