The West Midlands epithelial ovarian cancer adjuvant therapy trial

Clin Oncol (R Coll Radiol). 1993;5(1):1-5. doi: 10.1016/s0936-6555(05)80682-x.

Abstract

In a multicentre prospective randomized controlled trial, single agent cisplatinum was compared with whole abdomino-pelvic moving strip radiotherapy in the management of Stage IC-III epithelial ovarian cancer patients who had no macroscopic residual disease after primary surgery. Over a 6-year period 40 eligible patients were recruited, 15 of whom had Stage III disease. The overall 5-year survival was 60% with no significant survival difference between the treatment groups. Acute toxicity was common in both arms and six (11%) patients experienced significant long term disability.

Publication types

  • Clinical Trial
  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chemotherapy, Adjuvant
  • Cisplatin / adverse effects
  • Cisplatin / therapeutic use*
  • Female
  • Humans
  • Middle Aged
  • Ovarian Neoplasms / mortality
  • Ovarian Neoplasms / therapy*
  • Postoperative Care
  • Prospective Studies
  • Radiotherapy / adverse effects
  • Radiotherapy / methods
  • Reoperation
  • Survival Rate
  • Time Factors

Substances

  • Cisplatin