Abstract
Intrarectal inoculation of rhesus monkeys with low doses of SIVmac led to a prolonged clinical and virological latency that was not observed for high intrarectal doses or for intravenous inoculation. Animals infected intrarectally with low virus doses remained negative for serum antibody responses to SIV for at least one year even though they readily transferred SIV to naive recipients via transfusion of whole blood.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Viral / blood
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Base Sequence
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DNA, Viral / genetics
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DNA, Viral / isolation & purification
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Disease Models, Animal
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HIV Infections / transmission
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HIV-1
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Intestinal Mucosa / microbiology
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Leukocytes, Mononuclear / microbiology
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Macaca mulatta
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Male
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Molecular Sequence Data
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Rectum / microbiology
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Simian Acquired Immunodeficiency Syndrome / etiology*
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Simian Acquired Immunodeficiency Syndrome / transmission
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Simian Immunodeficiency Virus / genetics
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Simian Immunodeficiency Virus / immunology
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Simian Immunodeficiency Virus / isolation & purification
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Time Factors
Substances
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Antibodies, Viral
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DNA, Viral