Computer-assisted individual estimation of radioiodine thyroid uptake in Grave's disease

Comput Methods Programs Biomed. 1993 May;40(1):33-41. doi: 10.1016/0169-2607(93)90047-o.

Abstract

A computer-assisted Bayesian individual estimation of radioiodine thyroid uptake kinetics for patients suffering from Grave's disease is proposed. The program provides a fast computation of the activity to be administered to a given patient to achieve a target thyroid absorbed dose. This determination relies upon the patient biological covariates and upon a small number of measurements performed during a preliminar kinetic study of radioiodine thyroid uptake. Our results indicate that a two-sample Bayesian approach is reliable when external thyroid counts are performed at 2 h and 168 h after a test dose and has advantages over conventional kinetic experiments in terms of patient acceptability. This method is implemented on widespread computers and interfaced with a patient database. An interactive user interface with in-line data checking is provided. The program could be also a tool to better study the relationship between the absorbed dose and the clinical effect.

MeSH terms

  • Adult
  • Aged
  • Algorithms
  • Bayes Theorem
  • Computer Simulation
  • Drug Therapy, Computer-Assisted*
  • Female
  • Graves Disease / drug therapy
  • Graves Disease / metabolism*
  • Humans
  • Iodine Radioisotopes / administration & dosage
  • Iodine Radioisotopes / pharmacokinetics*
  • Iodine Radioisotopes / therapeutic use
  • Male
  • Microcomputers
  • Middle Aged
  • Models, Biological
  • Software
  • Thyroid Gland / metabolism*

Substances

  • Iodine Radioisotopes