Lineage promiscuity in leukemia studies of T-cell receptor and immunoglobulin genes

Leuk Res. 1993 May;17(5):445-53. doi: 10.1016/0145-2126(93)90101-p.

Abstract

Using appropriate DNA probes, the configurations of the T-cell receptor beta-chain genes and immunoglobulin heavy-chain genes were studied in patients diagnosed as having the following malignancies: 7 chronic myeloid leukemia, 13 acute myeloblastic leukemia, 9 acute lymphocytic leukemia and 20 chronic lymphocytic leukemia. Rearrangements not corresponding to the immunotype were unexpectedly found in lineage neoplasias.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Burkitt Lymphoma / blood
  • Burkitt Lymphoma / genetics
  • Gene Rearrangement*
  • Gene Rearrangement, beta-Chain T-Cell Antigen Receptor*
  • Genes, Immunoglobulin*
  • Genotype
  • Humans
  • Immunophenotyping
  • Leukemia / blood
  • Leukemia / genetics*
  • Leukemia, Lymphocytic, Chronic, B-Cell / blood
  • Leukemia, Lymphocytic, Chronic, B-Cell / genetics
  • Leukemia, Prolymphocytic, T-Cell / blood
  • Leukemia, Prolymphocytic, T-Cell / genetics
  • Leukemia-Lymphoma, Adult T-Cell / blood
  • Leukemia-Lymphoma, Adult T-Cell / genetics