We evaluated the effect of hepatic arterial infusion chemotherapy (HAI) and intraportal infusion chemotherapy (IPI) for liver metastasis of colorectal cancer. Since 1980, 89 patients with colorectal cancer showed liver metastasis. Seven of these cases had undergone curative resection of colon tumor and hepatectomy (5 cases with HAI). Eleven cases had undergone colon tumor resection and HAI. Among the former, 3 cases with HAI are alive, and the postoperative survival rate after 2 years improved among the latter. Curative removal was carried out in 567 patients in the same period. Recurrence of liver metastasis was observed in 30 cases, in 13 cases of which hepatectomy with HAI was performed, with HAI only in another 9 cases. The three-year survival rate among the former was 41.1% and the one-year survival rate of the latter was 16.2%. From 1986 to 1988, we performed IPI in 24 cases of colorectal cancer to prevent liver metastasis. They had undergone curative resection. Recurrence of liver metastasis was observed in one case (4.2%), which was less than in the control group (9.3%). It is concluded that HAI and IPI are effective treatment for liver metastasis in colorectal cancer.