[Ergotamine-induced rectal stenosis in a patient with long-term migraine]

Leber Magen Darm. 1993 Jul;23(4):166-8.
[Article in German]

Abstract

A 36 year old woman was admitted to our hospital for treatment of a high-grade rectal stenosis of unknown origin. She had a history of migraine going back 10 years. On intensive questioning she admitted using up to 5 ergotamine-containing suppositories a day. On the basis of history and clinical investigations the rectal stenosis must be connected with the abuse of ergotamine-containing suppositories. This case demonstrates that patients with an unexplained rectal syndrome should be asked for analgetics-containing suppositories specifically. Only discontinuation of treatment in time can preserve the patient from development of a rectal stenosis. In case of a rectal stenosis surgical treatment can be avoided by means of endoscopic controlled dilatation.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adult
  • Aminopyrine / administration & dosage
  • Aminopyrine / adverse effects*
  • Biopsy
  • Caffeine
  • Colonoscopy
  • Dilatation
  • Drug Combinations
  • Ergotamine / administration & dosage
  • Ergotamine / adverse effects*
  • Female
  • Glycine / administration & dosage
  • Glycine / adverse effects
  • Glycine / analogs & derivatives*
  • Humans
  • Intestinal Obstruction / chemically induced*
  • Intestinal Obstruction / pathology
  • Intestinal Obstruction / therapy
  • Ischemia / chemically induced
  • Ischemia / pathology
  • Migraine Disorders / drug therapy*
  • Propylamines / administration & dosage
  • Propylamines / adverse effects*
  • Pyrazolones
  • Rectal Diseases / chemically induced*
  • Rectal Diseases / pathology
  • Rectal Diseases / therapy
  • Rectum / blood supply
  • Suppositories

Substances

  • Drug Combinations
  • Propylamines
  • Pyrazolones
  • Suppositories
  • caffeine, camylofin, ergotamine, mecloxamine, propyphenazone drug combination
  • Aminopyrine
  • Caffeine
  • Ergotamine
  • Glycine