Fibrinogen and fibrin derivatives in traumatized patients: relation to injury severity and posttraumatic pulmonary dysfunction

Haemostasis. 1993 Mar-Apr;23(2):91-7. doi: 10.1159/000216859.

Abstract

In a prospective study including 30 traumatized patients, levels of fibrinogen, fibrinopeptide A (FpA), fibrin monomers (FM) and fibrin degradation products (FbDP) were measured on admission and on days 1, 2, 3 and 7 after the incident. High levels of FpA, FM and FbDP were observed immediately after the trauma. Fibrinogen levels increased during the first 7 posttraumatic days whereas FpA and FM decreased. FbDP was significantly higher on day 7 than on day 3. All variables were to some extent correlated to the injury severity score. FbDP were significantly lower on the day after admission in 4 patients who developed pulmonary dysfunction compared with patients without this complication.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Craniocerebral Trauma / blood*
  • Craniocerebral Trauma / complications
  • Female
  • Fibrin / analysis*
  • Fibrin Fibrinogen Degradation Products / analysis*
  • Fibrinogen / analysis*
  • Fibrinolysis
  • Fibrinopeptide A / analysis*
  • Hemostasis
  • Humans
  • Male
  • Middle Aged
  • Multiple Trauma / blood*
  • Multiple Trauma / complications
  • Prospective Studies
  • Pulmonary Edema / etiology*
  • Pulmonary Edema / physiopathology
  • Severity of Illness Index

Substances

  • Fibrin Fibrinogen Degradation Products
  • Fibrinopeptide A
  • Fibrin
  • Fibrinogen