Bone marrow microenvironment of patients with systemic lupus erythematosus

J Rheumatol. 1993 Jun;20(6):967-71.

Abstract

In an attempt to clarify the hematologic abnormality in systemic lupus erythematosus (SLE), we studied the bone marrow microenvironment of 8 women with this disease. The number of fibroblast colonies was similar to that of healthy control individuals. Culture supernatants of monocytes obtained from the patients with SLE showed a diminished production of the hemopoietic growth factor required to stimulate bone marrow fibroblasts. As the activity of the humoral factor released from SLE monocytes was diminished, such a reduction may play a role in the pathogenesis of the hematologic abnormality seen in SLE.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bone Marrow / metabolism
  • Bone Marrow / pathology*
  • Bone Marrow Diseases / etiology
  • Colony-Forming Units Assay
  • Culture Media, Conditioned
  • Cytokines / biosynthesis
  • Female
  • Fibroblasts / pathology
  • Hematopoietic Cell Growth Factors / biosynthesis
  • Hematopoietic Stem Cells / metabolism
  • Hematopoietic Stem Cells / pathology
  • Humans
  • Lupus Erythematosus, Systemic / complications
  • Lupus Erythematosus, Systemic / metabolism
  • Lupus Erythematosus, Systemic / pathology*
  • Monocytes / metabolism
  • Monocytes / pathology

Substances

  • Culture Media, Conditioned
  • Cytokines
  • Hematopoietic Cell Growth Factors