Abstract
In an attempt to clarify the hematologic abnormality in systemic lupus erythematosus (SLE), we studied the bone marrow microenvironment of 8 women with this disease. The number of fibroblast colonies was similar to that of healthy control individuals. Culture supernatants of monocytes obtained from the patients with SLE showed a diminished production of the hemopoietic growth factor required to stimulate bone marrow fibroblasts. As the activity of the humoral factor released from SLE monocytes was diminished, such a reduction may play a role in the pathogenesis of the hematologic abnormality seen in SLE.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bone Marrow / metabolism
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Bone Marrow / pathology*
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Bone Marrow Diseases / etiology
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Colony-Forming Units Assay
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Culture Media, Conditioned
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Cytokines / biosynthesis
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Female
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Fibroblasts / pathology
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Hematopoietic Cell Growth Factors / biosynthesis
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Hematopoietic Stem Cells / metabolism
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Hematopoietic Stem Cells / pathology
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Humans
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Lupus Erythematosus, Systemic / complications
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Lupus Erythematosus, Systemic / metabolism
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Lupus Erythematosus, Systemic / pathology*
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Monocytes / metabolism
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Monocytes / pathology
Substances
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Culture Media, Conditioned
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Cytokines
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Hematopoietic Cell Growth Factors