Verucopeptin, a new antitumor antibiotic active against B16 melanoma. I. Taxonomy, production, isolation, physico-chemical properties and biological activity

Y Nishiyama; K Sugawara; K Tomita; H Yamamoto; H Kamei; T Oki

doi:10.7164/antibiotics.46.921

Verucopeptin, a new antitumor antibiotic active against B16 melanoma. I. Taxonomy, production, isolation, physico-chemical properties and biological activity

J Antibiot (Tokyo). 1993 Jun;46(6):921-7. doi: 10.7164/antibiotics.46.921.

Authors

Y Nishiyama¹, K Sugawara, K Tomita, H Yamamoto, H Kamei, T Oki

Affiliation

¹ Bristol-Myers Squibb Research Institute, Tokyo, Japan.

PMID: 8344873
DOI: 10.7164/antibiotics.46.921

Abstract

A new antitumor antibiotic verucopeptin was isolated from the culture broth of Actinomadura verrucosospora Q886-2. It should potent cytotoxicity and specific in vivo activity against B16 melanoma. Maximum T/C value (162%) was obtained by Q1D x 1 treatment schedule.

MeSH terms

Actinomycetales / chemistry*
Animals
Antibiotics, Antineoplastic / chemistry
Antibiotics, Antineoplastic / isolation & purification*
Antibiotics, Antineoplastic / pharmacology*
Chromatography, High Pressure Liquid
Depsipeptides*
Fermentation
Humans
Leukemia L1210 / drug therapy
Leukemia P388 / drug therapy
Male
Melanoma, Experimental / drug therapy
Mice
Microbial Sensitivity Tests
Peptides, Cyclic / chemistry
Peptides, Cyclic / isolation & purification
Peptides, Cyclic / pharmacology

Substances

Antibiotics, Antineoplastic
Depsipeptides
Peptides, Cyclic
verucopeptin