High dose tamoxifen in the treatment of recurrent high grade glioma: a report of clinical stabilization and tumour regression

Can J Neurol Sci. 1993 May;20(2):168-70. doi: 10.1017/s0317167100047788.

Abstract

We present a case of recurrent glioma, previously treated with maximal surgery and radiation in which a high dose of tamoxifen has stabilized the tumour clinically and has resulted in it's radiologic regression. Given tamoxifen's relative lack of toxicity, it might serve as a useful adjuvant in the treatment of recurrent glioma.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Brain Neoplasms / diagnostic imaging
  • Brain Neoplasms / drug therapy*
  • Brain Neoplasms / pathology
  • Frontal Lobe / diagnostic imaging*
  • Frontal Lobe / pathology
  • Glioma / diagnostic imaging
  • Glioma / drug therapy*
  • Glioma / pathology
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Recurrence
  • Tamoxifen / administration & dosage
  • Tamoxifen / therapeutic use*
  • Tomography, X-Ray Computed

Substances

  • Tamoxifen