Longitudinal data (N = 785) collected during Ss high school years (1971-1973) and in 1981 were used to assess the influence of adolescent drug use on adult job behaviors, job satisfaction, and adverse terminations while accounting for concurrent adult drug use, years of drug use, and adolescent achievement motivation. Relationships were minimal between adolescent drug use and adult work-related indicators in confirmatory factor analyses (CFAs) and predictive path models. Although significantly related in the CFAs, higher adolescent achievement motivation did not predict less adult drug use when adolescent drug use was included as a control. Less achievement motivation in adolescence significantly predicted more negative job behaviors and less job satisfaction, but not terminations. Correlations were significant between more adolescent drug use and less adolescent achievement motivation and between adult job problems and adult drug use.