Present study comprises of 44 patients with Acute Myocardial Infarction. Their QRS score was correlated with Infarct Size by estimating the CPKMB levels and the post infarction complications during hospital stay. A statistically significant correlation was found between the 2 parameters of QRS score and infarct size (r = 0.75). It was better in anterior wall infarction (r = 0.96) than in inferior wall infarction (r = 0.64). The interobserver agreement between 2 observers for QRS score was excellent (rho = 0.99) QRS score was found to be a good prognostic indicator in the post infarction phase.