Abstract
The paper presents the data characterizing parameters of specific and nonspecific immunity in BALB/c mice immunized with gamma-ray-inactivated Machupo virus antigen or its formalinized antigen. The gamma-ray inactivated preparation was shown to be more immunogenic for BALB/c mice. A certain relationship between the time course of activity of nonspecific immunity factors in the immunized animals and the protective activity of the preparation under study was also noted. The decisive role of the T-cell part of the immune system was demonstrated in the resistance of this model animal to Machupo virus infection.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Animals
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Animals, Suckling
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Antibody Formation
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Antigens, Viral / drug effects
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Antigens, Viral / immunology*
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Antigens, Viral / radiation effects
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Arenaviruses, New World / drug effects
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Arenaviruses, New World / immunology*
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Arenaviruses, New World / radiation effects
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Hemorrhagic Fever, American / immunology*
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Hemorrhagic Fever, American / prevention & control
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Immunity, Cellular
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Immunity, Innate
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Immunization* / methods
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Mice
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Mice, Inbred BALB C / immunology*
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Vaccines, Inactivated / immunology
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Vaccines, Inactivated / radiation effects
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Viral Vaccines / immunology
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Viral Vaccines / radiation effects
Substances
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Antigens, Viral
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Vaccines, Inactivated
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Viral Vaccines