Translocation of CD3D gene in an acute myeloid leukemia (M5) with t(11;17)(q23;21)

Cancer Genet Cytogenet. 1993 Dec;71(2):173-5. doi: 10.1016/0165-4608(93)90026-i.

Abstract

Cytogenetic studies in patients with acute leukemia showed structural abnormalities on chromosome 11 at band q23 in five cases. Four of these had acute lymphoblastic leukemia (ALL) associated with t(4;11)(q21;q23) and one case had acute nonlymphoblastic leukemia (ANLL) (M5) associated with t(11;17)(q23;q21). We examined the CD3D and c-ets-1 genes in the t(11;17)(q23;q21) patient to ascertain any association between them and the chromosome change. In situ hybridization results showed that unlike in other studied cases with rearrangements of 11q23, the CD3D gene in the t(11;17)(q23;21) is transposed to the der(17) chromosome, providing evidence for a different breakpoint in the 11q23 region.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • CD3 Complex / genetics*
  • Centromere
  • Chromosome Mapping
  • Chromosomes, Artificial, Yeast
  • Chromosomes, Human, Pair 11 / ultrastructure*
  • Chromosomes, Human, Pair 17 / ultrastructure*
  • DNA Probes
  • Female
  • Humans
  • In Situ Hybridization
  • Infant, Newborn
  • Leukemia, Monocytic, Acute / genetics*
  • Translocation, Genetic*

Substances

  • CD3 Complex
  • DNA Probes