Chromosomal assignment of the human smg GDP dissociation stimulator gene to human chromosome 4q21-q25

Hum Genet. 1993 Dec;92(6):629-30. doi: 10.1007/BF00420952.

Abstract

The 3'-end of the cDNA encoding the smg GDP dissociation stimulator (smg GDS) protein shares 100% homology with the previously published expressed sequence tag 00038 site. This site extends the 3'-end of the smg GDS gene by 212 bp. It has been localized to human chromosome 4. Here, we have refined the localization of smg GDP to human chromosome 4q21-q25 using a mapping panel of rodent/human somatic cell hybrids containing different parts of chromosome 4. This chromosomal localization of smg GDP to 4q21-25 overlaps with a region of allele loss in primary hepatocellular carcinoma (4q13-q26).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Chromosome Mapping*
  • Chromosomes, Human, Pair 4*
  • Fungal Proteins / genetics*
  • GTP-Binding Proteins / genetics*
  • Humans
  • Hybrid Cells
  • Molecular Sequence Data
  • Oligonucleotides
  • Polymerase Chain Reaction
  • Sequence Homology
  • rap GTP-Binding Proteins

Substances

  • Fungal Proteins
  • Oligonucleotides
  • GTP-Binding Proteins
  • rap GTP-Binding Proteins