Augmentation of murine tumor necrosis factor production by amphotericin B in vitro and in vivo

Y Tokuda; M Tsuji; M Yamazaki; S Kimura; S Abe; H Yamaguchi

doi:10.1128/AAC.37.10.2228

Augmentation of murine tumor necrosis factor production by amphotericin B in vitro and in vivo

Antimicrob Agents Chemother. 1993 Oct;37(10):2228-30. doi: 10.1128/AAC.37.10.2228.

Authors

Y Tokuda¹, M Tsuji, M Yamazaki, S Kimura, S Abe, H Yamaguchi

Affiliation

¹ Department of Microbiology and Immunology, School of Medicine, Teikyo University, Tokyo, Japan.

Abstract

Murine peritoneal macrophages were preincubated with amphotericin B (AMPH) and were then stimulated with bacterial lipopolysaccharide or streptococcal preparation (OK432). These macrophages produced a large amount of tumor necrosis factor. When administered to mice, the priming activity of amphotericin B for tumor necrosis factor production in vivo was also observed.

Publication types

Comparative Study

MeSH terms

Amphotericin B / pharmacology*
Animals
Humans
Lipopolysaccharides / pharmacology
Macrophage Activation / drug effects
Macrophages, Peritoneal / drug effects
Macrophages, Peritoneal / metabolism
Male
Mice
Mice, Inbred C3H
Tumor Necrosis Factor-alpha / biosynthesis*

Substances

Lipopolysaccharides
Tumor Necrosis Factor-alpha
Amphotericin B