Abstract
In this report we demonstrate that an alpha-3 acetylcholine receptor subunit transcriptional variant originates through alternative splicing of a complementary sequence of the right arm of an Alu element. This element is located within the 5.1 Kb intron found between exons 5 and 6 of the alpha-3 acetylcholine receptor subunit gene. The transcriptional variant originates from the normal splicing process and carries an in-frame stop codon. If translated, it should encode for a peptide lacking the 4th transmembrane domain of the normal subunit.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Alternative Splicing*
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Base Sequence
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Exons / genetics
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Genetic Variation
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Genome, Human
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Humans
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Introns / genetics
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Molecular Sequence Data
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RNA, Antisense / genetics*
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Receptors, Cholinergic / genetics*
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Repetitive Sequences, Nucleic Acid / genetics*
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Sequence Homology, Nucleic Acid
Substances
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RNA, Antisense
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Receptors, Cholinergic
Associated data
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GENBANK/L14791
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GENBANK/L14792
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GENBANK/L14793
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GENBANK/L14794
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GENBANK/L14795
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GENBANK/L14796
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GENBANK/L14797
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GENBANK/L14798
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GENBANK/L18973
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GENBANK/L24897