Abstract
The molecular pathogenesis of diffuse large-cell lymphoma (DLCL), the most frequent and clinically relevant type of lymphoma, is unknown. A gene was cloned from chromosomal translocations affecting band 3q27, which are common in DLCL. This gene, BCL-6, codes for a 79-kilodalton protein that is homologous with zinc finger-transcription factors. In 33 percent (13 of 39) of DLCL samples, but not in other types of lymphoid malignancies, the BCL-6 gene is truncated within its 5' noncoding sequences, suggesting that its expression is deregulated. Thus, BCL-6 may be a proto-oncogene specifically involved in the pathogenesis of DLCL.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Cell Line
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Chromosomes, Human, Pair 3
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DNA, Complementary
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DNA-Binding Proteins / genetics
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Exons
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Gene Rearrangement
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Humans
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Introns
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Lymphoma, Large B-Cell, Diffuse / genetics*
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Molecular Sequence Data
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Proto-Oncogene Mas
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Proto-Oncogene Proteins / genetics
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Proto-Oncogene Proteins c-bcl-6
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Proto-Oncogenes / genetics*
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Sequence Homology, Amino Acid
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Transcription Factors / genetics
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Translocation, Genetic
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Zinc Fingers / genetics*
Substances
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DNA, Complementary
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DNA-Binding Proteins
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MAS1 protein, human
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Proto-Oncogene Mas
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Proto-Oncogene Proteins
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Proto-Oncogene Proteins c-bcl-6
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Transcription Factors