A comparison of the effect of propofol or thiopentone on the incidence and severity of suxamethonium-induced myalgia

Anaesth Intensive Care. 1994 Apr;22(2):147-9. doi: 10.1177/0310057X9402200204.

Abstract

We conducted a prospective, randomised single-blind study in 48 adult women undergoing laparoscopic gynaecological surgery to assess the incidence of suxamethonium-induced myalgia. Anaesthesia was induced with either thiopentone or propofol. All other aspects of clinical care were standardised between the groups. The propofol group had a significantly lower incidence of suxamethonium myalgia (19%) compared with the thiopentone group (63%) (P < 0.05). The mechanism of this effect is not understood.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Anesthesia, Intravenous*
  • Female
  • Genitalia, Female / surgery
  • Humans
  • Incidence
  • Laparoscopy
  • Middle Aged
  • Muscular Diseases / chemically induced*
  • Muscular Diseases / physiopathology
  • Pain / chemically induced*
  • Pain / physiopathology
  • Pain Measurement
  • Propofol / pharmacology*
  • Prospective Studies
  • Single-Blind Method
  • Succinylcholine / adverse effects*
  • Thiopental / pharmacology*

Substances

  • Succinylcholine
  • Thiopental
  • Propofol