Morphologic effects of a sulfur(IV) aerosol on the nasal cavity of beagle dogs

Toxicol Lett. 1994 Jun;72(1-3):145-50. doi: 10.1016/0378-4274(94)90021-3.

Abstract

Morphologic changes were observed in nasal cavities of beagle dogs after long-term exposure to a respirable sulfur(IV) aerosol at a concentration equivalent to a sulfur dioxide (SO2) concentration of 0.6 mg/m3. The changes were characterized by a thickened epithelial layer resulting from epithelial proliferation, by a loss of secretory material, and by moderate mononuclear cell infiltration.

MeSH terms

  • Administration, Inhalation
  • Aerosols
  • Air Pollutants / toxicity
  • Animals
  • Dogs
  • Male
  • Nasal Cavity / anatomy & histology
  • Nasal Cavity / cytology
  • Nasal Cavity / drug effects*
  • Oxidation-Reduction
  • Sulfur / chemistry
  • Sulfur / toxicity*
  • Sulfur Dioxide / chemistry
  • Sulfur Dioxide / toxicity
  • Sulfur Oxides / chemistry
  • Sulfur Oxides / toxicity
  • Time Factors

Substances

  • Aerosols
  • Air Pollutants
  • Sulfur Oxides
  • Sulfur Dioxide
  • Sulfur