Cytogenetic analysis of a granulocytic sarcoma showed a 46,XX,der(X)t(X;1) (q28;q22), inv(3)(p21q27), inv(9)(p13q22),t(12;22)(p11;q11) karyotype. In addition, bone marrow aspirate disclosed the presence of cells with a 46,XX,inv(3)(p21q27),inv(9)(p13q22)(p11;q11) chromosomal pattern while the patient was clinically aleukemic. This case demonstrates that chromosomal abnormalities other than the classical t(8;21) can also be associated with granulocytic sarcoma.