Lack of response to corticosteroids and pulse cyclophosphamide therapy in Cogan's syndrome

G Vaiopoulos; P P Sfikakis; B Skoumas; E Kavouklis; E Doukas; P Kaklamanis

doi:10.1007/BF02229876

Lack of response to corticosteroids and pulse cyclophosphamide therapy in Cogan's syndrome

Clin Rheumatol. 1994 Mar;13(1):110-2. doi: 10.1007/BF02229876.

Authors

G Vaiopoulos¹, P P Sfikakis, B Skoumas, E Kavouklis, E Doukas, P Kaklamanis

Affiliation

¹ Department of Internal Medicine, University of Athens School of Medicine, Laiko General Hospital, Greece.

PMID: 8187429
DOI: 10.1007/BF02229876

Abstract

A 17-year-old girl with Cogan's syndrome is described. Total and irreversible hearing loss occurred which was unresponsive to corticosteroids and immunosuppressive therapy. The girl died a year later from subarachnoid haemorrhage. The lethal prognosis in Cogan's syndrome despite the available treatment is emphasized.

Publication types

Case Reports

MeSH terms

Adolescent
Adrenal Cortex Hormones / therapeutic use*
Cyclophosphamide / therapeutic use*
Fatal Outcome
Female
Hearing Loss, Sensorineural / drug therapy
Humans
Keratitis / drug therapy
Syndrome
Vasculitis / drug therapy*
Vestibular Diseases / drug therapy*

Substances

Adrenal Cortex Hormones
Cyclophosphamide