Paternal pericentric inversion of chromosome 4 as a cause of recurrent pregnancy loss

G C Wolf; J Mao; L Izquierdo; G Joffe

doi:10.1136/jmg.31.2.153

Paternal pericentric inversion of chromosome 4 as a cause of recurrent pregnancy loss

J Med Genet. 1994 Feb;31(2):153-5. doi: 10.1136/jmg.31.2.153.

Authors

G C Wolf¹, J Mao, L Izquierdo, G Joffe

Affiliation

¹ Department of Obstetrics and Gynecology, University of New Mexico School of Medicine, Albuquerque 87131.

Abstract

A paternal pericentric inversion of chromosome 4 was ascertained through karyotype analysis of an abortus specimen proven to be 46,XX,rec(4),dup q, inv (4)(p13q28). The relationship of paternal pericentric inversion to pregnancy loss is discussed, and a recommendation for karyotype analysis of recurrent abortion specimens is made.

Publication types

Case Reports

MeSH terms

Abortion, Habitual / etiology*
Adult
Chromosome Inversion*
Chromosomes, Human, Pair 4*
Fathers
Female
Humans
Karyotyping
Male
Models, Genetic
Pregnancy