Abstract
The long term efficacy of GVG was studied in patients with drug resistant CPC and CPC plus secondarily generalized seizures. GVG was started as monotherapy followed by add-on therapy with carbamazepine (CBZ), phenobarbital (PB), valproate (VPA). The results suggest: 1) loss of efficacy of gamma-vinyl-GABA during long-term use, and 2) at present, GVG appears to be an effective safe antiepileptic drug for initial monotherapy.
Publication types
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Clinical Trial
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English Abstract
MeSH terms
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Adolescent
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Adult
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Aminocaproates / therapeutic use*
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Anticonvulsants / therapeutic use
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Carbamazepine / therapeutic use
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Dose-Response Relationship, Drug
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Drug Evaluation
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Drug Therapy, Combination
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Epilepsy, Complex Partial / drug therapy
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Epilepsy, Complex Partial / physiopathology*
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Female
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Humans
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Italy
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Male
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Middle Aged
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Phenobarbital / therapeutic use
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Placebos
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Seizures / drug therapy*
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Valproic Acid / therapeutic use
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Vigabatrin
Substances
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Aminocaproates
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Anticonvulsants
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Placebos
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Carbamazepine
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Valproic Acid
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Vigabatrin
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Phenobarbital