Abstract
The majority of viral glycoproteins that undergo post-translational proteolysis are cleaved by ubiquitous intracellular proteases; however, a minority are cleaved by secreted proteases available only in a few host systems. The interplay of viral glycoproteins and cellular proteases may have a pivotal role in the spread of infection, host range and pathogenicity.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Binding Sites / genetics
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Consensus Sequence
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Endopeptidases / metabolism*
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Glycoproteins / genetics
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Glycoproteins / metabolism
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Humans
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Molecular Sequence Data
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Protein Processing, Post-Translational
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Viral Proteins / genetics
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Viral Proteins / metabolism
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Virus Diseases / metabolism
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Virus Diseases / microbiology
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Viruses / genetics
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Viruses / metabolism
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Viruses / pathogenicity*
Substances
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Glycoproteins
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Viral Proteins
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Endopeptidases