Mechanisms of electrical defibrillation: impact of new experimental defibrillator waveforms

Am Heart J. 1994 Apr;127(4 Pt 2):970-7. doi: 10.1016/0002-8703(94)90075-2.

Abstract

Six possible explanations for why some biphasic waveforms have lower defibrillation thresholds than monophasic waveforms of the same duration are as follows: (1) the impedance for the second phase of the biphasic shock is very low because electrode polarization develops during the first phase; (2) the large change in voltage between the first and second phases of a biphasic waveform is responsible for the increased defibrillation efficacy; (3) biphasic waveforms cause less severe detrimental effects in regions of high potential gradient; (4) the first phase of the biphasic waveform restores activity of the sodium channels, which makes defibrillation easier for the second phase; (5) the potential gradient required for defibrillation is less for biphasic waveforms than for monophasic waveforms; and (6) biphasic waveforms are better able to stimulate the myocardium to induce new action potentials or to cause refractory period prolongation. Evidence shows that, while a few of these proposed mechanisms are incorrect, several of the others may together contribute to the general superiority of biphasic waveforms.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Action Potentials / physiology
  • Animals
  • Atrial Fibrillation / therapy
  • Electric Countershock / methods*
  • Electric Impedance
  • Humans
  • Ventricular Fibrillation / therapy