Abstract
The effect of clozapine, an atypical antipsychotic medication, in five patients with treatment-resistant schizophrenia or schizoaffective disorder and borderline intellectual functioning or mental retardation (MR) was studied. Four of the five patients responded favorably to clozapine with few side effects. Progressive improvement in psychopathology, social functioning, and ability to participate in daily activities were noted.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adolescent
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Adult
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Clozapine / adverse effects
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Clozapine / therapeutic use*
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Dose-Response Relationship, Drug
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Drug Administration Schedule
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Female
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Humans
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Intellectual Disability / drug therapy*
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Intellectual Disability / psychology
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Male
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Psychiatric Status Rating Scales
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Psychotic Disorders / drug therapy*
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Psychotic Disorders / psychology
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Schizophrenia / drug therapy*
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Schizophrenic Psychology*