Abstract
Most human peripheral blood gamma delta T lymphocytes respond to hitherto unidentified mycobacterial antigens. Four ligands from Mycobacterium tuberculosis strain H37Rv that stimulated proliferation of a major human gamma delta T cell subset were isolated and partially characterized. One of these ligands, TUBag4, is a 5' triphosphorylated thymidine-containing compound, to which the three other stimulatory molecules are structurally related. These findings support the hypothesis that some gamma delta T cells recognize nonpeptidic ligands.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antigens, Bacterial / chemistry
-
Antigens, Bacterial / immunology*
-
Antigens, Bacterial / isolation & purification
-
Cells, Cultured
-
Chromatography, Ion Exchange
-
Humans
-
Ligands
-
Lymphocyte Activation*
-
Magnetic Resonance Spectroscopy
-
Mycobacterium tuberculosis / immunology*
-
Receptors, Antigen, T-Cell, gamma-delta / immunology*
-
T-Lymphocyte Subsets / immunology*
-
Thymine Nucleotides / analysis
-
Thymine Nucleotides / chemistry
-
Thymine Nucleotides / immunology*
-
Thymine Nucleotides / isolation & purification
Substances
-
Antigens, Bacterial
-
Ligands
-
Receptors, Antigen, T-Cell, gamma-delta
-
Thymine Nucleotides
-
thymidine 5'-triphosphate