Stimulation of human gamma delta T cells by nonpeptidic mycobacterial ligands

Science. 1994 Apr 8;264(5156):267-70. doi: 10.1126/science.8146660.

Abstract

Most human peripheral blood gamma delta T lymphocytes respond to hitherto unidentified mycobacterial antigens. Four ligands from Mycobacterium tuberculosis strain H37Rv that stimulated proliferation of a major human gamma delta T cell subset were isolated and partially characterized. One of these ligands, TUBag4, is a 5' triphosphorylated thymidine-containing compound, to which the three other stimulatory molecules are structurally related. These findings support the hypothesis that some gamma delta T cells recognize nonpeptidic ligands.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, Bacterial / chemistry
  • Antigens, Bacterial / immunology*
  • Antigens, Bacterial / isolation & purification
  • Cells, Cultured
  • Chromatography, Ion Exchange
  • Humans
  • Ligands
  • Lymphocyte Activation*
  • Magnetic Resonance Spectroscopy
  • Mycobacterium tuberculosis / immunology*
  • Receptors, Antigen, T-Cell, gamma-delta / immunology*
  • T-Lymphocyte Subsets / immunology*
  • Thymine Nucleotides / analysis
  • Thymine Nucleotides / chemistry
  • Thymine Nucleotides / immunology*
  • Thymine Nucleotides / isolation & purification

Substances

  • Antigens, Bacterial
  • Ligands
  • Receptors, Antigen, T-Cell, gamma-delta
  • Thymine Nucleotides
  • thymidine 5'-triphosphate