P1 aspartate-based peptide alpha-((2,6-dichlorobenzoyl)oxy)methyl ketones as potent time-dependent inhibitors of interleukin-1 beta-converting enzyme

J Med Chem. 1994 Mar 4;37(5):563-4. doi: 10.1021/jm00031a003.
No abstract available

MeSH terms

  • Amino Acid Sequence
  • Aspartic Acid / analogs & derivatives*
  • Aspartic Acid / chemical synthesis
  • Aspartic Acid / pharmacology
  • Caspase 1
  • Cathepsin B / antagonists & inhibitors
  • Cell Line
  • Chlorobenzoates / chemical synthesis*
  • Chlorobenzoates / pharmacology
  • Humans
  • Kinetics
  • Metalloendopeptidases / antagonists & inhibitors*
  • Molecular Sequence Data

Substances

  • Chlorobenzoates
  • N-benzyloxycarbonyl-3-amino-5-carboxy-2-oxopent-1-yl 2,6-dichlorobenzoate
  • Aspartic Acid
  • Cathepsin B
  • Caspase 1
  • Metalloendopeptidases