Immunohistochemical localization of gonadotropin-associated peptide (GAP) in the human hypothalamus

N Andoh; H Ohtani; I Satoh; N Sasano; T Mukada; N Yanaihara; H Nagura

doi:10.1620/tjem.171.97

Immunohistochemical localization of gonadotropin-associated peptide (GAP) in the human hypothalamus

Tohoku J Exp Med. 1993 Sep;171(1):97-9. doi: 10.1620/tjem.171.97.

Authors

N Andoh¹, H Ohtani, I Satoh, N Sasano, T Mukada, N Yanaihara, H Nagura

Affiliation

¹ Department of Pathology, Tohoku University School of Medicine, Sendai.

PMID: 8122260
DOI: 10.1620/tjem.171.97

Abstract

GAP was immunohistochemically localized for the first time in the human hypothalamus. GAP-immunoreactivity was present in the cytoplasm of neuronal cells in the arcuate nucleus. GAP-immunoreactive nerve fibers were also present in the primary plexus around capillaries in the infundibular region. No GAP-immunoreactive neurons were detected in the paraventricular nuclei or supraoptic nuclei.

MeSH terms

Arcuate Nucleus of Hypothalamus / metabolism
Cytoplasm / metabolism
Gonadotropin-Releasing Hormone / metabolism*
Humans
Hypothalamus / metabolism*
Immunohistochemistry
Paraventricular Hypothalamic Nucleus / metabolism
Protein Precursors / metabolism*
Supraoptic Nucleus / metabolism

Substances

Protein Precursors
gonadotropin releasing hormone associated peptide
Gonadotropin-Releasing Hormone