Abstract
Genes for MGH-1, YOU-1, and YOU-2 extended-spectrum beta-lactamases have been cloned and sequenced. The gene for MGH-1 has the sequence of blaTEM-10, YOU-2 has that of blaTEM-12, and YOU-1 has that of blaTEM-26. All have evolved from blaTEM-1b but have the strong dual promoter sequence of blaTEM-2.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Cloning, Molecular
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Klebsiella pneumoniae / enzymology*
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Klebsiella pneumoniae / genetics*
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beta-Lactamases / genetics*
Substances
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beta-Lactamases
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beta-lactamase TEM-1
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beta-lactamase TEM-2