The human paired domain gene PAX7 (Hup1) maps to chromosome 1p35-1p36.2

Genomics. 1993 Jul;17(1):249-51. doi: 10.1006/geno.1993.1315.

Abstract

The human PAX7 gene encodes a protein containing a domain homologous to the Drosophila paired box first described in three segmentation genes. In addition to the paired box, the gene contains the conserved octapeptide and a paired-type homeobox. Two of the five known human PAX genes have been implicated in human disorders so far. Here we have used a somatic cell hybrid panel to localize PAX7 to human chromosome 1. In situ hybridization shows that PAX7 is confined to the short arm of chromosome 1 at 1p35-1p36.2.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Human, Pair 1*
  • Cricetinae
  • Drosophila / genetics
  • Genes*
  • Genes, Homeobox*
  • Homeodomain Proteins*
  • Humans
  • Hybrid Cells
  • In Situ Hybridization
  • Mice
  • Molecular Sequence Data
  • Muscle Proteins / genetics*
  • Nerve Tissue Proteins / genetics*
  • Organ Specificity
  • PAX7 Transcription Factor
  • Sequence Homology, Nucleic Acid
  • Species Specificity

Substances

  • Homeodomain Proteins
  • Muscle Proteins
  • Nerve Tissue Proteins
  • PAX7 Transcription Factor
  • PAX7 protein, human
  • Pax7 protein, mouse