Possible association of c-Harvey-Ras-1 (HRAS-1) marker with autism

J Hérault; A Perrot; C Barthélémy; M Büchler; C Cherpi; M Leboyer; D Sauvage; G Lelord; J Mallet; J P Müh

doi:10.1016/0165-1781(93)90094-w

Possible association of c-Harvey-Ras-1 (HRAS-1) marker with autism

Psychiatry Res. 1993 Mar;46(3):261-7. doi: 10.1016/0165-1781(93)90094-w.

Authors

J Hérault¹, A Perrot, C Barthélémy, M Büchler, C Cherpi, M Leboyer, D Sauvage, G Lelord, J Mallet, J P Müh

Affiliation

¹ National Institute for Health and Medical Research, Tours, France.

PMID: 8098541
DOI: 10.1016/0165-1781(93)90094-w

Abstract

We tested for an association between autism and genes coding for enzymes involved in monoaminergic metabolism and for a linked marker, c-Harvey-Ras-1 (HRAS 1), using restriction fragment length polymorphisms. We did not find evidence of an association between autism and genes coding for tyrosine hydroxylase, dopamine-beta-hydroxylase (DBH), and tryptophan hydroxylase. However, we report a positive association between autism and the locus containing the gene for HRAS-1.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Autistic Disorder / genetics*
Child
Child, Preschool
Dopamine beta-Hydroxylase / genetics
Female
Gene Frequency
Genetic Markers / genetics*
Humans
Intellectual Disability / genetics
Male
Polymorphism, Restriction Fragment Length*
Proto-Oncogene Proteins p21(ras) / genetics*
Tryptophan Hydroxylase / genetics
Tyrosine 3-Monooxygenase / genetics

Substances

Genetic Markers
Tyrosine 3-Monooxygenase
Tryptophan Hydroxylase
Dopamine beta-Hydroxylase
HRAS protein, human
Proto-Oncogene Proteins p21(ras)