Aggravation of ischemic neuronal damage in the rat hippocampus by impairment of histaminergic neurotransmission

Brain Res. 1993 Jan 29;602(1):165-8. doi: 10.1016/0006-8993(93)90259-p.

Abstract

Delayed damage to hippocampal CA1 pyramidal cells was observed in rats subjected to cerebral ischemia caused by 10 min of 4-vessel occlusion. Animals pretreated with alpha-fluoromethylhistidine, a suicide inhibitor of histidine decarboxylase, showed significantly more necrotic cells than did control animals. Mepyramine (H1-antagonist) and (R) alpha-methylhistamine (H3-agonist), but not zolantidine (H2-antagonist), significantly aggravated the delayed neuronal death. These results suggest that histaminergic neurons have a protective role, probably via H1-receptors, in the development of delayed neuronal death caused by cerebral ischemia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Benzothiazoles
  • Brain Ischemia / chemically induced*
  • Brain Ischemia / pathology
  • Cell Death / drug effects
  • Hippocampus / blood supply*
  • Hippocampus / cytology
  • Histamine Agonists / toxicity
  • Histamine H1 Antagonists / toxicity
  • Histamine H2 Antagonists / toxicity
  • Male
  • Methylhistamines / toxicity
  • Methylhistidines / toxicity
  • Neurons / drug effects*
  • Phenoxypropanolamines
  • Piperidines / toxicity
  • Pyrilamine / toxicity
  • Rats
  • Rats, Wistar
  • Receptors, Histamine / drug effects*
  • Synaptic Transmission / drug effects*
  • Thiazoles / toxicity

Substances

  • Benzothiazoles
  • Histamine Agonists
  • Histamine H1 Antagonists
  • Histamine H2 Antagonists
  • Methylhistamines
  • Methylhistidines
  • Phenoxypropanolamines
  • Piperidines
  • Receptors, Histamine
  • Thiazoles
  • alpha-methylhistamine
  • alpha-fluoromethylhistidine
  • Pyrilamine
  • zolantidine