Effects induced by BC 264, a selective agonist of CCK-B receptors, on morphine-dependent rats

Pharmacol Biochem Behav. 1994 Jun;48(2):363-9. doi: 10.1016/0091-3057(94)90539-8.

Abstract

The aim of this study was to investigate the possible interaction between neuronal cholecystokinin (CCK) and opiate dependence. Rats were made dependent to morphine and the ability of cholecystokinin-octapeptide (CCK-8) and Tyr(SO3H)-gNle-mGly-Trp-(NMe)Nle-Asp-Phe-NH2 (BC 264), a selective agonist of CCK-B receptors, to induce signs of morphine withdrawal after ICV injection was tested. Behavioral responses were compared to those occurring during the naloxone-precipitated morphine withdrawal syndrome. In contrast to naloxone, CCK-8 (0.1, 1, and 10 micrograms, ICV) did not precipitate any sign of withdrawal. BC 264 (0.1, 1, and 10 micrograms, ICV) induced a strong hyperlocomotion and wet dog shakes in morphine-dependent rats, the latter effect also observed in nondependent animals. In rats receiving acute morphine, BC 264 induced an opposite effect (i.e., blockade of morphine-induced hyperactivity). Taken together, these results suggest that CCK plays only a minor role in the expression of morphine physical dependence.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Behavior, Animal / drug effects*
  • Cholecystokinin / administration & dosage
  • Cholecystokinin / analogs & derivatives*
  • Cholecystokinin / pharmacology
  • Injections, Intraventricular
  • Male
  • Molecular Sequence Data
  • Morphine Dependence / psychology*
  • Motor Activity / drug effects
  • Naloxone / pharmacology
  • Peptide Fragments / administration & dosage
  • Peptide Fragments / pharmacology*
  • Rats
  • Rats, Wistar
  • Receptors, Cholecystokinin / drug effects*
  • Substance Withdrawal Syndrome / psychology

Substances

  • BC 264
  • Peptide Fragments
  • Receptors, Cholecystokinin
  • Naloxone
  • Cholecystokinin