Translocation 8;21 associated with acute nonlymphocytic leukemia in a Down syndrome child

Cancer Genet Cytogenet. 1994 Aug;76(1):72-3. doi: 10.1016/0165-4608(94)90076-0.

Abstract

A boy with Down syndrome who developed acute nonlymphocytic leukemia (ANLL/M2) at the age of 40 months is presented. Chromosomal analysis of cultured peripheral blood cells without mitogen revealed a constitutional abnormality, trisomy 21, associated with the acquired chromosome change t(8;21)(q22;q22).

Publication types

  • Case Reports

MeSH terms

  • Child, Preschool
  • Chromosomes, Human, Pair 21*
  • Chromosomes, Human, Pair 8*
  • Down Syndrome / complications
  • Down Syndrome / genetics*
  • Humans
  • Karyotyping
  • Leukemia, Myeloid, Acute / complications
  • Leukemia, Myeloid, Acute / genetics*
  • Male
  • Translocation, Genetic*