Dehydrozingerone and its analogues as inhibitors of nonenzymatic lipid peroxidation

Abstract

The antioxidant property of dehydrozingerone and its analogs were investigated in the ferric-ascorbate induced lipid peroxidation model in rat brain homogenate. All the non phenolic compounds were either inactive or less active, while phenolic compounds with substitution at both meta positions were found to be more active than dehydrozingerone. Based on their IC50 values several of these compounds are more potent than vitamin E and hence may be of potential use in various diseases caused by oxidant stress.