Influence of Tołpa Peat Preparation on haemostasis in rats

Acta Pol Pharm. 1993;50(6):507-11.

Abstract

The influence of Tołpa Peat Preparation (TPP) on certain parameters of haemostasis was studied. The present results indicate that TPP (100, 200 and 300 mg/kg p.o.) had no influence on the bleeding time, clotting time, thrombin time, prothrombin time, kaolin-kephalin time, euglobulin lysis time, the concentration of fibrinogen, the platelet count and ADP-induced platelet aggregation. No changes in animals after long-term treatment with TPP (100 mg/kg for two weeks) were found either. In in vitro studies TPP given in concentrations 10(-5), 10(-4), 10(-3) and 10(-2) g/cm3 was used and certain changes of the studied parameters, probably caused by the presence of high salt content in this substance, were observed.

MeSH terms

  • Amino Acids / pharmacology*
  • Animals
  • Bleeding Time
  • Carbohydrates / pharmacology*
  • Drug Combinations
  • Hemostasis / drug effects*
  • Humic Substances / pharmacology*
  • Male
  • Platelet Aggregation / drug effects
  • Platelet Count / drug effects
  • Prothrombin Time
  • Rats
  • Rats, Wistar
  • Soil
  • Thrombin Time
  • Uronic Acids / pharmacology*

Substances

  • Amino Acids
  • Carbohydrates
  • Drug Combinations
  • Humic Substances
  • Soil
  • Tolpa
  • Uronic Acids