Unique change of pancreastatin-like immunoreactivity in cerebrospinal fluid by aging

Neurosci Lett. 1994 Mar 28;170(1):179-82. doi: 10.1016/0304-3940(94)90268-2.

Abstract

Using a specific antiserum for the C-terminal glycine amide region of human pancreastatin (PST), pancreastatin-like immunoreactivity (PST-LI) was measured in cerebrospinal fluid (CSF) from 447 subjects (368 +/- 10.8 pmol/l, mean +/- S.E.M.) free from endocrine diseases. The CSF contents of PST-LI showed a mountain-shape type change which peaked at 40 years of age. The highest concentration was found in the group of ages 40-49 years old (412 +/- 22.9 pmol/l) and the lowest concentration was found in the group of ages 80-89 years old (293.2 +/- 45.2 pmol/l) among various age groups. Gel chromatographic examination revealed the presence of two major forms (MW 13,500 and 5,400) of PST-LI in CSF. Because of the character of this antibody, the large molecular form is possibly an N-terminally elongated PST and the other may be PST-52. This may be the first report on the unique age-related change of PST concentration in CSF.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging / cerebrospinal fluid*
  • Chromatography, Gel
  • Chromogranin A
  • Female
  • Humans
  • Male
  • Middle Aged
  • Molecular Weight
  • Pancreatic Hormones / cerebrospinal fluid*
  • Pancreatic Hormones / chemistry
  • Pancreatic Hormones / immunology
  • Radioimmunoassay

Substances

  • Chromogranin A
  • Pancreatic Hormones
  • pancreastatin