Phase II study of the failure of vincristine and bleomycin for previously treated children with metastatic neuroblastoma: a report from the Childrens Cancer Study Group

Abstract

Twenty-two patients with previously treated but progressive stage IV neuroblastoma received combination therapy with vincristine (1.0 mg/m2) followed in 6 hours by bleomycin (15 mg/m2). Therapy was administered twice weekly. No responses were seen in the 19 patients who received four or more doses of the bleomycin-vincristine combination.