[A pharmacokinetic analysis of Gd-DTPA enhancement in MRT in breast carcinoma]

Rofo. 1994 Jun;160(6):518-23. doi: 10.1055/s-2008-1032470.
[Article in German]

Abstract

Dynamic Gd-DTPA enhanced MR of the breast was performed in one single slice in 27 patients with suspicious nodular lesions. The results could be histologically verified in all cases. A rapid spin-echo sequence with a time resolution of 8.75 s was used for the dynamic examination. The signal changes were analysed using a pharmacokinetic model which allowed parametrization of the contrast enhancement and transformation of the data into colour coded parameter images. The parameters allowed reliable distinction of 9 benign from 18 malignant lesions (p < 0.05 for "amplitude", p < 0.001 for "k21"). One fibroadenoma could not be distinguished from the carcinomas. Lymph node metastases and the pharmacokinetic parameter amplitude correlated significantly (p < 0.05).

Publication types

  • English Abstract

MeSH terms

  • Adult
  • Aged
  • Breast Neoplasms / diagnosis
  • Breast Neoplasms / metabolism*
  • Carcinoma / diagnosis
  • Carcinoma / metabolism*
  • Contrast Media / pharmacokinetics*
  • Diagnosis, Differential
  • Discriminant Analysis
  • Female
  • Gadolinium / pharmacokinetics*
  • Gadolinium DTPA
  • Humans
  • Image Enhancement / instrumentation
  • Image Enhancement / methods*
  • Magnetic Resonance Imaging / instrumentation
  • Magnetic Resonance Imaging / methods*
  • Magnetic Resonance Imaging / statistics & numerical data
  • Middle Aged
  • Organometallic Compounds / pharmacokinetics*
  • Pentetic Acid / analogs & derivatives*
  • Pentetic Acid / pharmacokinetics
  • Pilot Projects

Substances

  • Contrast Media
  • Organometallic Compounds
  • Pentetic Acid
  • Gadolinium
  • Gadolinium DTPA