Inhibition of hepatic extramedullary haemopoiesis by nucleoprotein of heterologous rotavirus strain in infant mice

Acta Virol. 1993 Dec;37(6):466-74.

Abstract

Infant mice (NMRI strain) showed the inhibition of hepatic extramedullary haemopoiesis by oral inoculation of a 100 ID50 dose of EB rotavirus and nucleoprotein of SA-11 rotavirus (serotype 3). The extramedullary haemopoiesis was observed by oral inoculation of surface protein VP7 of SA-11 rotavirus and in control (placebo administered) mice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, Viral*
  • Capsid / pharmacology
  • Capsid Proteins*
  • Hematopoiesis, Extramedullary / drug effects*
  • Liver / pathology
  • Mice
  • Mice, Inbred Strains
  • Nucleoproteins / pharmacology*
  • Rotavirus / chemistry*
  • Rotavirus Infections / blood*
  • Rotavirus Infections / pathology
  • Viral Proteins / pharmacology*

Substances

  • Antigens, Viral
  • Capsid Proteins
  • Nucleoproteins
  • VP7 protein, Rotavirus
  • Viral Proteins