[The appearance of antinucleosome antibodies precedes that of anti-double-stranded DNA and anti-histones in murine lupus]

Rev Med Interne. 1993;14(10):980. doi: 10.1016/s0248-8663(05)80098-0.
[Article in French]

Abstract

Collected samples serum of 30 MRL lpr/lpr and 15 MRL MP +/+ were tested by ELISA on purified mononucleosomes and its individual components, dsDNA and histones. Anti-mononucleosome antibodies can be detected as early as 10 and 23 week of age for MRL lpr/lpr and MP +/+, respectively, and arose before anti-dsDNA and anti-histone antibodies.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Antibodies, Antinuclear / immunology*
  • DNA / immunology
  • Histones / immunology
  • Lupus Erythematosus, Systemic / immunology*
  • Mice
  • Mice, Mutant Strains
  • Nucleosomes / immunology*

Substances

  • Antibodies, Antinuclear
  • Histones
  • Nucleosomes
  • DNA