[Cardiac complications of halofantrine: continuous electrocardiographic study (holter) in 20 patients]

E Monlun; P Le Metayer; M C Receveur; K Bouabdallah; D Neau; M Longy-Boursier; M Le Bras

doi:10.1016/s0248-8663(05)80072-4

[Cardiac complications of halofantrine: continuous electrocardiographic study (holter) in 20 patients]

Rev Med Interne. 1993;14(10):954. doi: 10.1016/s0248-8663(05)80072-4.

[Article in French]

Authors

E Monlun¹, P Le Metayer, M C Receveur, K Bouabdallah, D Neau, M Longy-Boursier, M Le Bras

Affiliation

¹ Clinique médicale propédeutique, médecine interne et maladies tropicales, hôpital Saint André, CHU Bordeaux, France.

PMID: 8009050
DOI: 10.1016/s0248-8663(05)80072-4

Abstract

Three cases of long QT-interval due to halofantrine were documented in 1992 in France. Two of them had a congenital long QT-interval (Romano-Ward syndrome). We performed a prospective study of cardiac monitoring in 20 patients taking halofantrine. Minimal ECG changes were noted with lengthening of the QT-interval. Systematic ECG is necessary before giving halofantrine.

Publication types

English Abstract

MeSH terms

Antimalarials / adverse effects*
Electrocardiography, Ambulatory
Heart Diseases / chemically induced*
Heart Diseases / prevention & control
Humans
Phenanthrenes / adverse effects*
Prospective Studies

Substances

Antimalarials
Phenanthrenes
halofantrine